Key result
Transthoracic echocardiography demonstrated decreased coronary flow reserve in 14 patients with coronary artery disease compared to 12 normal subjects.
Why the study?
Does transthoracic echocardiographic assessment of coronary sinus blood flow detect impaired coronary flow reserve in patients with coronary artery disease compared to normal subjects?
Case-Control (n=26)
Does transthoracic echocardiographic assessment of coronary sinus blood flow detect impaired coronary flow reserve in patients with coronary artery disease compared to normal subjects?
Transthoracic echocardiography with pulse wave Doppler can measure coronary sinus blood flow to detect impaired coronary flow reserve in patients with coronary artery disease.
Answers are grounded in this paper and cite their sources.
Supports TTE coronary sinus flow for CFR assessment in CAD; leaves open validation and clinical utility.
In order to establish whether coronary flow reserve (CFR) can be measured by transthoracic echocardiography (TTE) with pulse wave Doppler echocardiography, 14 patients with coronary artery disease (CAD) and 12 normal subjects were studied. Coronary sinus blood flow was measured at rest and 2 minutes after intravenous injection of 0.56 mg/kg dipyridamole (DP). CFR was calculated as the DP to rest flow ratio. Patients with CAD were found to have significantly decreased CFR when compared to normal subjects. These findings suggest that TTE may be useful in diagnosing CAD.
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Tabel et al. (2006) conducted a case-control in Coronary artery disease (n=26). Transthoracic echocardiography (TTE) with pulse wave Doppler vs. Normal subjects was evaluated on Coronary flow reserve (CFR). Transthoracic echocardiography demonstrated decreased coronary flow reserve in 14 patients with coronary artery disease compared to 12 normal subjects.
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