Key result
LV GLS and mechanical dispersion enhance HFpEF diagnosis and phenotyping during exercise and afterload challenges.
Why the study?
Diagnosis of HFpEF is complicated by overlapping comorbidities such as obesity and hypertension, highlighting the need for tools like left ventricular global longitudinal strain to detect subtle systolic dysfunction.
Advanced echocardiographic strain imaging, including global longitudinal strain, mechanical dispersion, and left atrial strain, enhances the diagnosis and phenotyping of HFpEF, especially during hemodynamic stress.
Strain parameters may aid HFpEF phenotyping under stress; hypothesis-generating and requires prospective validation before clinical adoption.
Heart Failure with Preserved Ejection Fraction (HFpEF) is an increasing challenge in cardiology, marked by impairments in systolic and/or diastolic function.HFpEF patients often present with exercise intolerance, yet diagnosis is complicated by overlapping comorbidities, such as obesity and hypertension.Left ventricular Global Longitudinal Strain (GLS) enables the detection of subtle systolic dysfunction, with studies indicating a stronger correlation between GLS and exercise capacity than ejection fraction (EF).In exercise echocardiography, GLS displays a characteristic bimodal
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Hortegal et al. (2024) conducted a review in Heart Failure with Preserved Ejection Fraction (HFpEF). Left Ventricular Global Longitudinal Strain (GLS) and Mechanical Dispersion (MD) was evaluated. Left ventricular global longitudinal strain and mechanical dispersion enhance the diagnosis and phenotyping of heart failure with preserved ejection fraction, particularly during exercise and afterload challenges.
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