Left ventricular global longitudinal strain is associated with exercise capacity in failing hearts with preserved and reduced ejection fraction
Why the study?
Is left ventricular global longitudinal strain superior to ejection fraction in identifying reduced exercise capacity in heart failure patients?
Population
100 heart failure patients, including 37 patients with HFpEF.
Comparison
Echocardiographic assessment of left ventricular… vs Left ventricular ejection fraction (EF)
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
May enhance detection of impaired exercise capacity versus EF in HF; hypothesis-generating and requires prospective validation before practice change.
Structured PICO
Is left ventricular global longitudinal strain superior to ejection fraction in identifying reduced exercise capacity in heart failure patients?
P
Population
100 heart failure patients (mean age 56 ± 12 years, NYHA functional class 2.5 ± 0.9, mean EF 42 ± 19%), including 37 patients with HFpEF (EF ≥50% and echocardiographic diastolic dysfunction).
I
Intervention
Echocardiographic assessment of left ventricular global longitudinal strain (GLS)
C
Comparator
Left ventricular ejection fraction (EF)
O
Outcome
Correlation with exercise capacity assessed by peak oxygen uptake (VO2)surrogate
Left ventricular global longitudinal strain is superior to ejection fraction for identifying reduced exercise capacity in heart failure patients, and reveals impaired systolic function even in HFpEF.
Cite This Study
Hasselberg et al. (2014) studied this question.