Key result
LV GLS predicts heart transplantation criteria at a -5.7% cut-off.
Why the study?
GLS predicts functional capacity in HFpEF and prognosis in HFrEF, but its correlation with CPET parameters and ability to identify heart transplantation candidates in systolic HF was unclear.
Does Global Longitudinal Strain predict functional capacity and heart transplantation criteria in patients with systolic heart failure?
Comparison
GLS and LVEF correlation with CPET parameters
Design
Prospective observational study
Authors
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GLS may support transplant evaluation in systolic HF; hypothesis-generating and requires prospective validation before practice change.
Observational (n=26)
Does Global Longitudinal Strain predict functional capacity and heart transplantation criteria in patients with systolic heart failure?
Effect estimate: AUC 0.88
p-value: p=0.03
Global longitudinal strain is significantly associated with cardiopulmonary exercise test parameters and can accurately predict criteria for heart transplantation referral in patients with systolic heart failure.
Maia et al. (2019) conducted an observational in Systolic heart failure (n=26). Left ventricular global longitudinal strain (GLS) was evaluated on Heart transplantation criteria (VO2 < 14 mL/kg/min and VE/VCO2 slope > 35) (AUC 0.88, p=0.03). Left ventricular global longitudinal strain predicted heart transplantation criteria with an area under the ROC curve of 0.88 (sensitivity 75%, specificity 83%, P=0.03) at a cut-off of -5.7%.
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