Key result
High Lipoprotein(a) levels (≥50 mg/dL) were not associated with incident atrial fibrillation (HR 0.98) but increased ischemic stroke risk by 42% among participants without AF (HR 1.42; 95% CI 1.07-1.90).
Why the study?
Are high Lipoprotein(a) levels associated with increased risk of incident atrial fibrillation and ischemic stroke in a community-based cohort?
Population
10,127 participants from the community-based ARIC cohort free of stroke at baseline, baseline age 62.7±5.6…
Comparison
High Lipoprotein(a) levels (≥50 mg/dL) vs Low Lipoprotein(a) levels (<10 mg/dL)
Design
Cohort
Follow-up
Median 13.9 years for AF and 15.8 years for stroke
Authors
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High Lp(a) may identify stroke risk in non-AF individuals; leaves open causal effects and need for prospective trials.
Cohort (n=10,127)
Yes
Are high Lipoprotein(a) levels associated with increased risk of incident atrial fibrillation and ischemic stroke in a community-based cohort?
Effect estimate: HR 0.98 (95% CI 0.82-1.17)
High Lipoprotein(a) levels are associated with an increased risk of ischemic stroke in individuals without atrial fibrillation, but not with incident atrial fibrillation itself.
Aronis et al. (2017) conducted a cohort in Atrial fibrillation and ischemic stroke (n=10,127). Lipoprotein(a) ≥50 mg/dL vs. Lipoprotein(a) <10 mg/dL was evaluated on Incident atrial fibrillation (HR 0.98, 95% CI 0.82-1.17). High Lipoprotein(a) levels (≥50 mg/dL) were not associated with incident atrial fibrillation (HR 0.98) but increased ischemic stroke risk by 42% among participants without AF (HR 1.42; 95% CI 1.07-1.90).
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