Key result
Diameter stenosis and LAD location linked to ~140% greater odds of lower FFR.
Why the study?
The study was conducted to assess the correlation between diameter stenosis, lesion length, location, diffuse coronary disease, and fractional flow reserve.
Do angiographic parameters predict fractional flow reserve in lesions with stable coronary artery disease?
Observational (n=384)
Do angiographic parameters predict fractional flow reserve in lesions with stable coronary artery disease?
Angiographic diameter stenosis and LAD location correlate with lower FFR, whereas lesion length and proximal branches do not, highlighting the limitations of relying solely on visual or angiographic assessment for certain lesion characteristics.
Aims: Assess the correlation between diameter stenosis, lesion length, location, diffuse coronary disease and with fractional flow reserve (FFR). Methods/Results: We performed quantitative coronary analysis analysis on 384 lesions with stable coronary artery disease undergoing FFR assessment. Vessels were 59.1% left anterior descending artery (LAD), 16.1% left circumflex artery and 14.8% right coronary artery. Median diameter stenosis was 58% ± 2.5 and median lesion length was 10 mm ± 7.36. 21% of vessels were diffusely diseased. Lesions were 33.6% proximal, 44% mid-vessel and 12% distal. Median FFR was 0.85. Diameter stenosis correlated with lower FFR (p < 0.005, odds ratio [OR]: 2.4 [95% CI: 0.99–5.63]). There was no association between lesion length, location, number of proximal side branches and FFR. Vessels with diffuse disease had a nonsignificant trend for lower FFR (0.84 vs 0.85, p = 0.375, OR: 1.26 [95% CI: 0.76–2.09]). LAD lesions had significantly lower FFR compared with non-LAD (p < 0.001, OR: 2.55 [95% CI: 1.61–4.04]); including left circumflex artery and right coronary artery lesions (p = 0.001, OR: 3.4 [95% CI: 1.7–6.9]) and p = 0.02, OR: 2.55 [95% CI: 1.17–4.34]). Conclusion: FFR is not related to lesion length, location or number of proximal branches.
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Nour et al. (2022) conducted an observational in Stable coronary artery disease (n=384). Angiographic lesion characteristics (diameter stenosis, length, location) was evaluated on Lower fractional flow reserve (FFR) (OR 2.4, 95% CI 0.99-5.63, p=<0.005). Diameter stenosis and LAD location were significantly correlated with lower FFR (OR 2.4; 95% CI 0.99-5.63 and OR 2.55; 95% CI 1.61-4.04, respectively), whereas lesion length was not.
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