Key result
SK channel inhibition with NS8593 and UCL1684 significantly increased the atrial effective refractory period and decreased AF duration in both normotensive and hypertensive rats.
Why the study?
Do SK channel inhibitors NS8593 and UCL1684 reduce atrial fibrillation duration and increase atrial effective refractory period in aged hypertensive rats?
RCT
Randomly assigned
Do SK channel inhibitors NS8593 and UCL1684 reduce atrial fibrillation duration and increase atrial effective refractory period in aged hypertensive rats?
SK channel inhibition demonstrates antiarrhythmic properties in an in vivo rat model of hypertension-induced atrial remodeling, suggesting a potential therapeutic target for atrial fibrillation.
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SK inhibition merits preclinical follow-up in hypertension; leaves open translation to human AF therapy.
Diness et al. (2011) conducted an RCT in Atrial fibrillation with hypertension-induced atrial remodeling. NS8593 and UCL1684 (SK channel inhibitors) vs. Vehicle was evaluated on Atrial effective refractory period and AF duration. SK channel inhibition with NS8593 and UCL1684 significantly increased the atrial effective refractory period and decreased AF duration in both normotensive and hypertensive rats.
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