Key result
Occupation of the myocyte alpha 1-receptor results in stimulation of cyclic AMP phosphodiesterase activity, enhancing the disappearance of cyclic AMP.
Population
Purified rat ventricular myocytes and membranes prepared from them
Comparison
Alpha 1-adrenergic stimulation with or without… vs Control conditions
Design
Preclinical
Authors
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Should not change alpha-blocker practice; leaves open whether this pathway modulates human myocyte contractility or arrhythmias.
Provides mechanistic evidence that alpha 1-adrenergic receptors in cardiac myocytes regulate cyclic AMP levels by stimulating phosphodiesterase activity.
Buxton et al. (1985) studied this question. Alpha 1-adrenergic stimulation was evaluated on Cyclic AMP metabolism and phosphodiesterase activity. Occupation of the myocyte alpha 1-receptor results in stimulation of cyclic AMP phosphodiesterase activity, enhancing the disappearance of cyclic AMP.
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