Key result
In rat hearts, cAMP increases actomyosin ATPase activity, but the addition of the alpha-adrenergic blocker prazosin reverses this effect and decreases overall protein phosphorylation.
Population
Quickly frozen rat hearts
Comparison
cAMP with or without alpha-adrenergic blocker vs Control (absence of added cAMP or prazosin)
Design
Preclinical
Authors
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Urges caution in cAMP modulation for cardiac therapies; leaves open intricate dose-dependent mechanisms in muscle regulation.
Alpha-adrenergic activity modulates the effect of cAMP on cardiac actomyosin ATPase activity, likely by inhibiting phosphatase activity.
McClellan et al. (1994) studied this question. cAMP and prazosin vs. Control (absence of cAMP/prazosin) was evaluated on Actomyosin ATPase activity and protein phosphorylation. In rat hearts, cAMP increases actomyosin ATPase activity, but the addition of the alpha-adrenergic blocker prazosin reverses this effect and decreases overall protein phosphorylation.
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