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Assesses genetic and nutritional factors impacting Helicobacter pylori infection risk, suggesting hypovitaminosis D plays a role.
• Human TLR9 polymorphisms (rs187084 and rs164640) are associated with an increased risk of H. pylori infection. • The TLR2 rs3804099 TT genotype is associated with higher serum vitamin D3 levels. • H. pylori -positive individuals have significantly lower vitamin D3 levels than controls, suggesting hypovitaminosis D might be an independent risk factor for infection. • These findings reveal a potential genetic–nutritional interplay in host susceptibility to H. pylori infection.
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Wang et al. (2026) studied this question.
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