Association of NLRP3 rs4612666 Gene Polymorphism with Helicobacter Pylori Infection Susceptibility a Case-Control Study Using Molecular and Statistical Analysis

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Helicobacter pylori infection is a major global health concern, associated with various gastrointestinal disorders such as peptic ulcers and gastric cancer, which result in significant morbidity and economic burden on healthcare systems. This study investigates the relationship between the NLRP3 rs4612666 gene polymorphism and susceptibility to H. pylori infection using a case-control design that involved 200 people. We employed molecular techniques and statistical analyses to evaluate the distributions of genotypes and alleles. Our findings indicated no significant difference in the distribution of NLRP3 rs4612666 genotypes between the infected group (C/C: 35.0%, C/T: 51.0%, T/T: 14.0%) and the non-infected group (C/C: 24.0%, C/T: 50.0%, T/T: 26.0%) with a p-value of 0.059. However, we did observe a statistically significant difference in allele frequencies, with allele C found in 60.5% of the infected group compared to 49.0% in the non-infected group (p=0.021), suggesting that allele C may be linked to a higher susceptibility to H. pylori infection. Despite these insights, the study has limitations, including a small sample size and a lack of clinical validation, highlighting the necessity for further research with larger cohorts to verify these associations. This research enhances our understanding of the genetic factors contributing to H. pylori infection, which could inform future diagnostic and therapeutic approaches, and emphasizes the need to explore additional genetic markers to deepen our understanding of the disease's pathogenesis.