Enteroviral meningoencephalitis in neonates was associated with mild to severe white matter damage on MRI in all 6 cases, leading to cerebral palsy in 2 infants.
Case Report (n=6)
Neonatal enteroviral meningoencephalitis can cause significant white matter damage resembling periventricular leukomalacia and may lead to long-term neurological sequelae such as cerebral palsy.
The authors report six neonates with enteroviral meningoencephalitis. Five infants presented with prolonged seizures, and one presented with systemic enteroviral disease. Cranial ultrasonography showed increased echogenicity in the periventricular white matter, and MRI confirmed mild to severe white matter damage in all infants, which looked similar to periventricular leukomalacia. Two infants developed cerebral palsy: one was neurologically suspect at age 18 months, and three were developmentally normal.
Verboon-Maciolek et al. (2006) conducted a case report in neonatal enterovirus meningoencephalitis (n=6). Enteroviral meningoencephalitis in neonates was associated with mild to severe white matter damage on MRI in all 6 cases, leading to cerebral palsy in 2 infants.