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eNOS-derived NO regulates metabolism and energy homeostasis primarily via cGMP signaling and protein S-nitrosylation.
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eNOS-derived nitric oxide is a critical regulator of metabolic homeostasis, suggesting that replenishing bioactive NO may be a therapeutic strategy for metabolic diseases.
Nitric oxide is an endogenously formed gas that acts as a signaling molecule in the human body. The signaling functions of nitric oxide are accomplished through two primer mechanisms: cGMP-mediated phosphorylation and the formation of S-nitrosocysteine on proteins. This review presents and discusses previous and more recent findings documenting that nitric oxide signaling regulates metabolic activity. These discussions primarily focus on endothelial nitric oxide synthase (eNOS) as the source of nitric oxide.
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Τενοπούλου et al. (2020) conducted a review in Metabolic regulation and cardiovascular disease. Nitric oxide (NO) signaling was evaluated. Endothelial nitric oxide synthase-derived nitric oxide regulates metabolic activity and energy homeostasis primarily through cGMP-mediated signaling and reversible protein S-nitrosylation.
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