Key result
The highest quartile of 2-hour plasma glucose significantly predicted incident type 2 diabetes in men with normal blood pressure (HR 12.2) and women with prehypertension (HR 5.84) over 8 years.
Why the study?
Do surrogate estimates of insulin resistance predict incident type 2 diabetes in persons with normal blood pressure or prehypertension?
Cohort (n=5,697)
Yes
Do surrogate estimates of insulin resistance predict incident type 2 diabetes in persons with normal blood pressure or prehypertension?
Effect estimate: HR 12.2 (95% CI 7.12-21.00)
p-value: p=<0.001
Metabolic variables associated with insulin resistance strongly predict the development of type 2 diabetes in Korean adults with normal blood pressure or prehypertension.
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May aid T2DM risk stratification in prehypertension; leaves open need for prospective validation before practice change.
Sung et al. (2016) conducted a cohort in Normal blood pressure or prehypertension (n=5,697). Highest quartile of 2-hour plasma glucose vs. Lowest quartile of 2-hour plasma glucose was evaluated on Incident type 2 diabetes (HR 12.2, 95% CI 7.12-21.00, p=<0.001). The highest quartile of 2-hour plasma glucose significantly predicted incident type 2 diabetes in men with normal blood pressure (HR 12.2) and women with prehypertension (HR 5.84) over 8 years.
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