Key result
Insulin resistance (highest vs lowest HOMA quintile) was independently associated with a higher prevalence of high blood pressure in normoglycemic Koreans (PR 1.540; 95% CI 1.341-1.768; P<0.001).
Why the study?
Does insulin resistance correlate with high blood pressure in normoglycemic Koreans?
Cross-Sectional (n=49,076)
Does insulin resistance correlate with high blood pressure in normoglycemic Koreans?
Effect estimate: Prevalence Ratio 1.540 (95% CI 1.341-1.768)
p-value: p=<0.001
Insulin resistance, BMI, and waist circumference are independently correlated with high blood pressure in normoglycemic Korean adults.
BACKGROUND: There is some controversy about the role of insulin resistance (IR) in the regulation of blood pressure (BP). Moreover, a large study of the association between BP and IR has not been conducted in normal glucose tolerance Asians. The present study investigated the relationships between IR, body mass index (BMI) and waist circumference and BP in normoglycemic Koreans. METHODS AND RESULTS: Anthropometric indices of adiposity, metabolic variables (fasting serum insulin and a homeostasis model assessment (HOMA) index of insulin sensitivity), BP and several cardiovascular risk factors were measured during a cross-sectional survey of 49,076 normoglycemic Korean subjects. A high BP was defined as a systolic BP >/=140 mmHg or a diastolic BP >/=90 mmHg. The prevalence of high BP by HOMA grading was 0.985 (95% confidence interval (CI) 0.857-1.132, p=0.835), 1.180 (95% CI 1.032-1.350, p=0.016), 1.289 (95% CI 1.129-1.472, p<0.001), and 1.540 (95% CI 1.341-1.768, p<0.001) times higher in subjects in the second, third, fourth, and fifth quintiles, respectively, compared with those in the first quintile. In addition, age, sex, waist circumference and BMI were found to be significantly associated with a high BP. CONCLUSION: IR, BMI and waist circumference are independently correlated with high BP in normoglycemic Koreans.
No takes yet. Share an insight, caveat, or question.
Sung et al. (2004) conducted a cross-sectional in High blood pressure in normoglycemic subjects (n=49,076). Insulin resistance (HOMA index) vs. Lowest HOMA index quintile was evaluated on High blood pressure (systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg) (Prevalence Ratio 1.540, 95% CI 1.341-1.768, p=<0.001). Insulin resistance (highest vs lowest HOMA quintile) was independently associated with a higher prevalence of high blood pressure in normoglycemic Koreans (PR 1.540; 95% CI 1.341-1.768; P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: