Hyperinsulinemia and Homeostasis Model Assessment of Insulin Resistance as Predictors of Hypertension: A 5-Year Follow-Up Study of Korean Sample
Why the study?
Do elevated serum insulin and HOMA(IR) predict incident hypertension in healthy, normotensive adults?
Population
10,894 apparently healthy and relatively lean Korean adults who were normotensive at baseline
Comparison
Elevated serum insulin and HOMA vs Lower serum insulin and HOMA(IR) (lower quartiles)
Design
Cohort
Follow-up
5 years
Authors
Discussion
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Member takes
Implication
May support risk stratification in normotensives; leaves open whether targeting insulin resistance prevents hypertension.
Structured PICO
Do elevated serum insulin and HOMA(IR) predict incident hypertension in healthy, normotensive adults?
P
Population
10,894 apparently healthy and relatively lean Korean adults who were normotensive at baseline
I
Intervention
Elevated serum insulin and HOMA(IR) (highest quartile)
C
Comparator
Lower serum insulin and HOMA(IR) (lower quartiles)
O
Outcome
Incident hypertensionhard clinical
High circulating insulin levels and HOMA(IR) are significant predictors of incident hypertension in relatively lean and healthy normotensive adults.
Cite This Study
Sung et al. (2011) studied this question.