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February 2, 2019Journal of Cardiovascular Electrophysiology

Characteristics of ventricular intracardiac electrograms of ventricular tachycardias originating from the epicardia in patients with an implantable cardioverter defibrillator

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Key result

VTs originating from the epicardium had significantly longer far-field VEGM duration compared to those from the endocardium (240 ± 49 ms vs 153 ± 45 ms; P=0.002).

Why the study?

It was not fully examined whether ventricular intracardiac electrograms recorded from an ICD via telemetry can determine the origin of ventricular tachycardia.

Can ventricular intracardiac electrograms recorded from an ICD predict the epicardial origin of ventricular tachycardia?

Population

15 patients with an ICD and 23 induced VTs with detected sites of origin

Design

Observational study

Authors

IKIwanari KawamuraElectrophysiologySFSeiji FukamizuElectrophysiologyMAMarina AraiTohoku University

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Implication

Far-field ICD electrograms may differentiate epicardial VT origin; hypothesis-generating and requires prospective validation before clinical adoption.

Study Design

Type

Observational (n=46)

Structured PICO

Can ventricular intracardiac electrograms recorded from an ICD predict the epicardial origin of ventricular tachycardia?

P
Population
15 patients with an implantable cardioverter defibrillator (ICD) who had 23 induced ventricular tachycardias (VTs) with detected sites of origin during VT study
I
Intervention
Analysis of far-field and near-field ventricular intracardiac electrograms (VEGMs) recorded via telemetry
C
Comparator
Comparison between VTs of epicardial origin (n=5) and endocardial origin (n=18)
O
Outcome
VEGM duration in far-field EGM, duration from onset to peak of VEGM, and V wave duration in tip-ring EGMsurrogate

Main Result

Absolute Event Rate: 240% vs 153%

p-value: p=0.002

Far-field ventricular intracardiac electrograms recorded via ICD telemetry can help differentiate epicardial from endocardial origins of ventricular tachycardia prior to ablation.

Cite This Study

Kawamura et al. (2019) conducted an observational in Ventricular tachycardia in patients with an implantable cardioverter defibrillator (n=46). Epicardial origin of VT vs. Endocardial origin of VT was evaluated on VEGM duration in far-field EGM (p=0.002). VTs originating from the epicardium had significantly longer far-field VEGM duration compared to those from the endocardium (240 ± 49 ms vs 153 ± 45 ms; P=0.002).

synapsesocial.com/papers/6a1545575347fbb1739f82b3https://doi.org/10.1111/jce.13854

Topics

Ventricular arrhythmiasCardiac device therapy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Value of Defibrillator Electrograms for Recognition of Clinical Ventricular Tachycardias and for Pace Mapping of Post-Infarction Ventricular Tachycardia2010 · 85 citations
  2. 2Magnetic Resonance–Based Anatomical Analysis of Scar-Related Ventricular Tachycardia2007 · 204 citations
  3. 3ECG Criteria to Identify Epicardial Ventricular Tachycardia in Nonischemic Cardiomyopathy2009 · 266 citations
  4. 4Implantable Defibrillator Electrograms and Origin of Left Ventricular Impulses: An Analysis of Regionalization Ability and Visual Spatial Resolution2011 · 14 citations
  5. 5Catheter Ablation of Ventricular Tachycardia in Structural Heart Disease2017 · 96 citations