Key result
Undersized mitral annuloplasty reduced anterobasal systolic wall thickening by ~50% and inhibited subendocardial systolic fiber shortening (-0.04 vs baseline -0.10; P<0.05) in an acute sheep model.
Why the study?
Does undersized mitral annuloplasty alter regional transmural LV wall strains and wall thickening mechanisms in a sheep model?
Does undersized mitral annuloplasty alter regional transmural LV wall strains and wall thickening mechanisms in a sheep model?
p-value: p=<0.05
Undersized mitral annuloplasty acutely impairs local systolic wall thickening and myocardial mechanics in the anterobasal region in a sheep model.
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May impair regional LV mechanics in sheep; challenges reverse remodeling consensus and leaves open human translation.
Cheng et al. (2006) studied Mitral regurgitation (animal model) (n=9). Undersized mitral annuloplasty vs. Baseline (before tightening suture) was evaluated on Regional transmural LV wall fiber and sheet strains and wall thickening mechanisms (p=<0.05). Undersized mitral annuloplasty reduced anterobasal systolic wall thickening by ~50% and inhibited subendocardial systolic fiber shortening (-0.04 vs baseline -0.10; P<0.05) in an acute sheep model.
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