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February 1, 1991Circulation ResearchOpen Access

Transmural myocardial deformation in the ischemic canine left ventricle.

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Why the study?

How does acute transmural myocardial ischemia alter two- and three-dimensional finite strains in the canine left ventricle?

Population

13 open-chest anesthetized dogs

Comparison

Acute transmural myocardial ischemia (5 minutes) vs Control period (pre-ischemia)

Design

Preclinical

Follow-up

5 minutes

Authors

FVFrancisco VillarrealUC San Diego Health SystemWLWilbur Y.W. LewVeterans Medical Research Foundation of San DiegoLWLewis K. WaldmanOncoMed (United States)

Discussion

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Overview

Complicates uniaxial strain interpretation during acute ischemia; leaves open whether 3D deformation metrics improve human risk stratification.

Key Points

  • This research investigates the impact of ischemia on myocardial deformation in the canine left ventricle.
  • Examined ischemic effects on two- and three-dimensional finite strains in 13 open-chest anesthetized dogs.
  • Analyzed circumferential and longitudinal deformations during acute transmural ischemia.
  • Measured end-diastolic strains and changes in transmural gradients of shortening and thickening.
  • After 5 minutes of ischemia, end-systolic in-plane lengthening in circumferential and longitudinal directions was equal.
  • Significant negative transverse shearing deformations were observed during ischemia.
  • Loss of normal end-systolic transmural gradients of shortening and thickening during ischemic conditions was noted.

Structured PICO

How does acute transmural myocardial ischemia alter two- and three-dimensional finite strains in the canine left ventricle?

P
Population
13 open-chest anesthetized dogs
I
Intervention
Acute transmural myocardial ischemia (5 minutes)
C
Comparator
Control period (pre-ischemia)
O
Outcome
Two- and three-dimensional finite strains (myocardial deformation)surrogate

Acute myocardial ischemia causes complex three-dimensional changes in ventricular deformation, including significant shearing and loss of normal transmural gradients, indicating that uniaxial measurements of ischemic myocardium are incomplete.

Cite This Study

Villarreal et al. (1991) studied this question.

synapsesocial.com/papers/6a154b5779ff98d0de4e6584https://doi.org/10.1161/01.res.68.2.368
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of ischemia on left ventricular regional function in the conscious dog1981 · 75 citations
  2. 2Gradients in fiber shortening and metabolism across ischemic left ventricular wall1986 · 37 citations
  3. 3Left ventricular epicardial deformation in isolated arrested dog heart1987 · 55 citations
  4. 4Subepicardial segmental function during coronary stenosis and the role of myocardial fiber orientation.1982 · 109 citations
  5. 5Fiber Orientation in the Canine Left Ventricle during Diastole and Systole1969 · 1,464 citations