Key result
Myocardial ischemia and reperfusion in dogs caused a significant transmural gradient of dysfunction in radial segments (24% endocardium vs 16% epicardium; P<0.05), but not in fiber segments.
Why the study?
Does ischemia/reperfusion cause a transmural gradient of dysfunction in stunned myocardium in dogs?
Population
Open-chest anesthetized dogs (n=8)
Comparison
15 minutes of left anterior descending coronary… vs Baseline (before occlusion)
Design
Preclinical
Follow-up
2 hours of reperfusion
Authors
Loading...
Fiber dysfunction may predominate over perfusion deficit in reperfusion stunning; challenges consensus and leaves open human relevance.
Does ischemia/reperfusion cause a transmural gradient of dysfunction in stunned myocardium in dogs?
Absolute Event Rate: 24% vs 16%
p-value: p=<0.05
Systolic fiber dysfunction, rather than the degree of perfusion deficit during the preceding ischemic period, may be the main determinant of myocardial dysfunction during reperfusion in stunned myocardium.
Mazhari et al. (2001) studied Stunned myocardium (n=8). Left anterior descending coronary artery occlusion and reperfusion vs. Epicardium (vs Endocardium) was evaluated on Transmural distribution of 3D systolic strains (radial segment thinning at end systole) (p=<0.05). Myocardial ischemia and reperfusion in dogs caused a significant transmural gradient of dysfunction in radial segments (24% endocardium vs 16% epicardium; P<0.05), but not in fiber segments.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: