Why the study?
Does enalapril reverse abnormal intrarenal sodium handling and sodium retention in patients with mild heart failure during high salt intake?
Does enalapril reverse abnormal intrarenal sodium handling and sodium retention in patients with mild heart failure during high salt intake?
In early or mild heart failure, defective proximal nephron sodium reabsorption leads to sodium retention during high salt intake, a physiological abnormality that is largely reversed by enalapril.
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Enalapril may normalize sodium retention in mild HF on high salt intake; leaves open clinical outcome benefits in prospective trials.
Volpe et al. (1997) studied this question.
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