December 16, 2005AJP Regulatory Integrative and Comparative Physiology
Hemodynamic and neuroendocrine responses to changes in sodium intake in compensated heart failure
Key result
A high-sodium diet in compensated heart failure patients increased cardiac index by 14% and decreased total peripheral resistance by 10% without excessive fluid retention.
Why the study?
Does a high-sodium diet compared to a low-sodium diet improve hemodynamic and neuroendocrine responses in patients with medically treated compensated heart failure?
Population
24 participants
Comparison
High-sodium diet (250 mmol/day) for 1 week vs Low-sodium diet (70 mmol/day) for 1 week
Design
RCT, randomized, balanced fashion
Follow-up
1 week per diet phase
Authors
Discussion
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Member takes
Implication
High sodium intake improves hemodynamics without excess retention in treated compensated HF; leaves open whether sodium restriction guidelines warrant revision.
Study Design
Type
RCT (n=24)
Randomization
randomized, balanced fashion
Structured PICO
Does a high-sodium diet compared to a low-sodium diet improve hemodynamic and neuroendocrine responses in patients with medically treated compensated heart failure?
P
Population
24 participants (12 compensated heart failure patients on ACE inhibitors and beta-blockers, and 12 age-matched controls) evaluated after 1 week of low and high sodium diets.
I
Intervention
High-sodium diet (250 mmol/day) for 1 week
C
Comparator
Low-sodium diet (70 mmol/day) for 1 week
O
Outcome
Hemodynamic and neuroendocrine responses (including body weight, plasma volume, cardiac index, stroke volume index, mean arterial pressure, total peripheral resistance, angiotensin II, norepinephrine, and pro-B-type natriuretic peptide) at rest and during bicycle exercisesurrogate
A high-sodium diet in medically treated compensated heart failure patients improves cardiac performance and suppresses vasoconstrictor hormones, challenging the routine advice for dietary sodium restriction.
Cite This Study
Damgaard et al. (2005) conducted an RCT in Compensated heart failure (n=24). High-sodium diet vs. Low-sodium diet (70 mmol/day) was evaluated on Hemodynamic and neuroendocrine responses. A high-sodium diet in compensated heart failure patients increased cardiac index by 14% and decreased total peripheral resistance by 10% without excessive fluid retention.