Key result
Total pulmonary vein isolation achieved freedom from symptomatic AF without antiarrhythmic drugs in 57% of persistent AF patients compared to 84% of paroxysmal AF patients (p=0.04).
Why the study?
Does total pulmonary vein isolation improve freedom from symptomatic AF in patients with persistent atrial fibrillation compared to paroxysmal atrial fibrillation?
Population
68 consecutive patients with paroxysmal or persistent atrial fibrillation, mean age 52 ± 10 years.
Comparison
Isolation of all four pulmonary veins by… vs Patients with paroxysmal atrial fibrillation
Design
Cohort
Follow-up
mean 11 months
Authors
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Lower single-procedure PVI success in persistent versus paroxysmal AF warrants individualized counseling; leaves open optimal ablation strategies for persistent AF.
Observational (n=68)
Does total pulmonary vein isolation improve freedom from symptomatic AF in patients with persistent atrial fibrillation compared to paroxysmal atrial fibrillation?
Absolute Event Rate: 57% vs 84%
p-value: p=0.04
Total pulmonary vein isolation is effective for both paroxysmal and persistent AF, though single-procedure success without antiarrhythmic drugs is higher in paroxysmal AF.
Matsuo et al. (2005) conducted an observational in Paroxysmal and persistent atrial fibrillation (n=68). Total pulmonary vein isolation vs. Paroxysmal AF group was evaluated on Freedom from symptomatic AF without any antiarrhythmic drug (AAD) therapy (p=0.04). Total pulmonary vein isolation achieved freedom from symptomatic AF without antiarrhythmic drugs in 57% of persistent AF patients compared to 84% of paroxysmal AF patients (p=0.04).
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