New insights into mechanisms of atrial fibrillation
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Key result
Atrial fibrillation is primarily triggered by ectopic foci in the pulmonary veins and sustained by structural remodeling and atrial fibrosis, which serve as emerging targets for novel therapies.
Design
Review
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Discussion
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Implication
May guide upstream AF therapy development targeting fibrosis; leaves open randomized validation before clinical adoption.
PICO
P
Population
Atrial Fibrillation
This review highlights the complex pathophysiology of atrial fibrillation, emphasizing the interplay between triggers, structural/electrical remodeling, and modifiers, which opens avenues for novel upstream therapies.
Cite This Study
Aldhoon et al. (2010) conducted a review in Atrial Fibrillation. Atrial fibrillation is primarily triggered by ectopic foci in the pulmonary veins and sustained by structural remodeling and atrial fibrosis, which serve as emerging targets for novel therapies.
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