Key result
Noninvasive LAPEq using MR spectrum shows ~0.91 correlation with invasive catheter measurement.
Why the study?
To explore how to accurately and quantitatively measure left atrial pressure using the equation method with mitral regurgitation spectrum.
Does noninvasive measurement of left atrial pressure using mitral regurgitation spectrum accurately correlate with invasive catheter measurement?
Observational (n=28)
Does noninvasive measurement of left atrial pressure using mitral regurgitation spectrum accurately correlate with invasive catheter measurement?
Noninvasive quantitative measurement of left atrial pressure using the mitral regurgitation spectrum equation method correlates well with invasive catheter measurements, offering a feasible noninvasive alternative.
Supports validation studies; leaves open whether noninvasive LAPEq can replace invasive measurement in practice.
To explore how to measure LAP Ep accurately and quantitatively, that is, the left atrial pressure (LAP) measured and calculated by equation method using mitral regurgitation spectrum. Methods The mitral regurgitation spectrum, pulmonary arteriolar wedge pressure (PAWP) and invasive arterial systolic pressure of radial artery of 28 patients were collected simultaneously, including 3 patients with rheumatic heart disease, 15 patients with mitral valve prolapse and 10 patients with coronary artery bypass grafting, patients with moderate or above aortic stenosis were excluded. LAP Bp (Doppler sphygmomanometer method), LAP Eq (Equation method) and LAP C (Catheter method) were measured synchronously, and the measurement results of the three methods were compared and analyzed. We designed a special intelligent Doppler spectrum analysis software to accurately measure LAP Eq . Results Found that there was no significant statistical difference between the measurement results of LAP C and LAP Eq (t = 0.954, P = 0.348),and significant correlation between the two methods [r = 0.908(0.844,0.964), P < 0.001]. Although the measurement results of LAP C and LAP BP are consistent in some patients, there are significant differences in the overall case and weak correlation between the two methods [r = 0.210, (−0.101, 0.510), P = 0.090]. In MVP patients with P1 or P3 prolapse, the peak pressure difference of MR was underestimated due to the serious eccentricity of MR, which affected the accuracy of LAP BP measurement. This study had been approved by the ethics committee of the northern theater general hospital ( K-2019-17), applied prospectively for clinical trial (No. Chictr 190023812) and invention patent application (No. 202210711862.X). Conclusions This study shows that there is a good correlation between LAP Eq and LAP C , which verifies that the noninvasive and direct quantitative measurement of left atrial pressure based on mitral regurgitation spectrum is feasible and has a good application prospect.
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Jin et al. (2022) conducted an observational in Mitral regurgitation in patients needing cardiac surgery (n=28). Equation method (LAPEq) using mitral regurgitation spectrum vs. Catheter method (LAPC) was evaluated on Correlation between LAPEq and LAPC (r 0.908, 95% CI 0.844, 0.964, p=<0.001). The noninvasive equation method (LAPEq) for measuring left atrial pressure using mitral regurgitation spectrum showed a strong correlation (r=0.908) with invasive catheter measurement.
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