Key result
The ratio of early diastolic mitral flow to early diastolic lateral mitral annulus velocity (E/Ea) demonstrated the strongest correlation with maximum left atrial pressure (r=0.74) and mean left atrial pressure (r=0.70) among all evaluated echocardiographic variables.
Why the study?
Does the echocardiographic E/Ea ratio accurately estimate left atrial pressure in dogs with mitral regurgitation?
Population
6 healthy beagle dogs with experimentally-induced mitral valve regurgitation via chordae tendineae rupture…
Comparison
Echocardiographic estimation of left atrial… vs Direct continuous measurement of left atrial…
Design
Preclinical
Follow-up
Approximately 9 months after surgery for experimental dogs
Authors
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Supports non-invasive LAP estimation in canine MR; hypothesis-generating and requires prospective validation before clinical adoption.
Does the echocardiographic E/Ea ratio accurately estimate left atrial pressure in dogs with mitral regurgitation?
Effect estimate: r=0.74
p-value: p=<0.05
The echocardiographic E/Ea ratio provides a precise and instant non-invasive estimation of maximum and mean left atrial pressure in dogs with mitral regurgitation.
Ishikawa et al. (2011) studied Mitral Valve Regurgitation (n=263). Echocardiographic estimation of left atrial pressure (E/Ea ratio) vs. Direct left atrial pressure measurement via radio telemetry was evaluated on Correlation between the ratio of early diastolic mitral flow to early diastolic lateral mitral annulus velocity (E/Ea) and maximum left atrial pressure (r=0.74, p=<0.05). The ratio of early diastolic mitral flow to early diastolic lateral mitral annulus velocity (E/Ea) demonstrated the strongest correlation with maximum left atrial pressure (r=0.74) and mean left atrial pressure (r=0.70) among all evaluated echocardiographic variables.