Key result
Myocardial infarction did not significantly increase proteinuria (303 vs 265 mg/24 h) in 5/6 nephrectomized rats compared to 5/6 nephrectomy alone, and ACEi therapy improved renal hemodynamics.
Why the study?
Does ACEi therapy improve renal hemodynamics and structural damage in 5/6 nephrectomized rats with myocardial infarction?
Does ACEi therapy improve renal hemodynamics and structural damage in 5/6 nephrectomized rats with myocardial infarction?
In a rat model of severe renal impairment, myocardial infarction does not further deteriorate structural renal damage, but impairs renal hemodynamics which can be improved with ACEi therapy.
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Does not support ACEi changes in human CKD post-MI; extends preclinical cardiorenal data but leaves translation open.
Windt et al. (2008) studied Myocardial infarction and severe renal function loss. Angiotensin-converting enzyme inhibitor (ACEi) vs. Vehicle was evaluated on Proteinuria and glomerulosclerosis. Myocardial infarction did not significantly increase proteinuria (303 vs 265 mg/24 h) in 5/6 nephrectomized rats compared to 5/6 nephrectomy alone, and ACEi therapy improved renal hemodynamics.
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