Why the study?
Does subtotal nephrectomy (uremia) increase myocardial infarct size following ischemia-reperfusion in rats?
Does subtotal nephrectomy (uremia) increase myocardial infarct size following ischemia-reperfusion in rats?
Uremia induced by subtotal nephrectomy significantly increases myocardial infarct size in rats, providing direct evidence for reduced ischemia tolerance in renal failure.
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May indicate uremic vulnerability to ischemia-reperfusion; leaves open translation to human CKD outcomes.
Dikow et al. (2004) studied this question.
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