July 1, 1983AJP Heart and Circulatory Physiology
Cardiorenal hemodynamics and sodium excretion in rats with myocardial infarction
Why the study?
Does acute volume loading affect sodium excretion and renal hemodynamics differently in rats with varying degrees of myocardial infarction compared to controls?
Population
Rats with myocardial infarction and control rats with no infarct
Comparison
Acute volume loading vs Control rats (no infarct)
Design
Preclinical
Follow-up
4 hours (for conscious rats)
Authors
Discussion
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Member takes
Implication
Impaired natriuresis to volume load in post-MI rats should not yet change practice; leaves open renal mechanisms in experimental HF.
Structured PICO
Does acute volume loading affect sodium excretion and renal hemodynamics differently in rats with varying degrees of myocardial infarction compared to controls?
P
Population
Rats with myocardial infarction (small to moderate: 10-40% of left ventricular circumference; large: >40%) and control rats with no infarct
I
Intervention
Acute volume loading (saline load by gavage in conscious rats; intravenous volume expansion with balanced salt solution in anesthetized rats)
C
Comparator
Control rats (no infarct)
O
Outcome
Sodium (Na+) excretionsurrogate
Rats with myocardial infarction exhibit an impaired natriuretic response to volume loading, which occurs even with minimal changes in ventricular pumping capacity.
Cite This Study
Hostetter et al. (1983) studied this question.