Key result
Enalapril significantly reduced cardiomegaly in rats with chronic myocardial infarction (3.97 vs 4.29 mg/g), whereas salt restriction had no effect on cardiac weight progression.
Why the study?
Does salt restriction or enalapril prevent cardiomegaly in a rat model of chronic myocardial infarction?
Population
Rat model of chronic myocardial infarction
Comparison
Salt restriction or the ACE inhibitor enalapril vs Control rats and infarcted rats without…
Design
Preclinical
Authors
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Does not support salt restriction for post-MI cardiomegaly; animal data leave open translation of enalapril benefit to human chronic HF.
Does salt restriction or enalapril prevent cardiomegaly in a rat model of chronic myocardial infarction?
Absolute Event Rate: 3.97% vs 4.29%
In a rat model of chronic myocardial infarction, ACE inhibition with enalapril prevented progressive cardiomegaly and pulmonary congestion, whereas salt restriction did not.
Hodsman et al. (1988) studied Chronic myocardial infarction. Enalapril and salt restriction vs. Control (infarction without treatment) was evaluated on Cardiac weight (cardiomegaly). Enalapril significantly reduced cardiomegaly in rats with chronic myocardial infarction (3.97 vs 4.29 mg/g), whereas salt restriction had no effect on cardiac weight progression.
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