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April 17, 2007Clinical and Experimental Pharmacology and Physiology

Effect of Enalapril Treatment on the Sensitivity of Cardiopulmonary Reflexes in Rats With Myocardial Infarction

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Why the study?

Does enalapril improve the sensitivity of cardiopulmonary reflexes in rats with myocardial infarction?

Population

Wistar rats 30 days after myocardial infarction (and sham-operated controls)

Comparison

Enalapril 10 mg/kg per day vs Vehicle (0.9% NaCl)

Design

Preclinical

Follow-up

30 days

Authors

TATadeu Uggere de AndradeUniversidade de BrasíliaVPVicente de Paulo Teixeira PintoUniversidade Federal do CearáAMA RS MedeirosUniversidade Federal do Espírito Santo

Discussion

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Implication

Supports enalapril effects in rat MI model; hypothesis-generating and leaves open human translation.

Key Points

  • To evaluate the effect of chronic enalapril therapy on cardiopulmonary reflex sensitivity and organ hypertrophy 30 days after myocardial infarction in rats.
  • Wistar rats were assigned to four groups: sham vehicle, infarcted vehicle (0.9% NaCl), sham enalapril, and infarcted enalapril (10 mg/kg per day).
  • Serotonin injection was used to trigger the Bezold-Jarisch reflex (measured via heart rate reduction), and saline overload was applied to test volume-sensitive cardiopulmonary reflexes (measured via renal volume and sodium excretion).
  • Infarct size and organ-to-bodyweight ratios for the heart chambers, lungs, liver, and kidneys were assessed post-mortem to determine hypertrophy.
  • Untreated infarcted rats showed blunted cardiopulmonary reflex sensitivity, right ventricular and pulmonary hypertrophy, reduced systolic and mean arterial pressure, and elevated heart rate compared with sham groups.
  • Enalapril treatment normalized cardiopulmonary reflex responses to serotonin and saline overload and reduced hypertrophy in infarcted rats, while partially improving systolic arterial pressure.

Structured PICO

Does enalapril improve the sensitivity of cardiopulmonary reflexes in rats with myocardial infarction?

P
Population
Wistar rats 30 days after myocardial infarction (and sham-operated controls)
I
Intervention
Enalapril 10 mg/kg per day
C
Comparator
Vehicle (0.9% NaCl)
O
Outcome
Sensitivity of cardiopulmonary reflexes (Bezold-Jarisch reflex and volume-sensitive reflex)surrogate

Enalapril normalizes cardiopulmonary reflex sensitivity and reduces cardiac hypertrophy in a rat model of myocardial infarction.

Cite This Study

Andrade et al. (2007) studied this question.

synapsesocial.com/papers/6a85467032b8a2b0ded6a85bhttps://doi.org/10.1111/j.1440-1681.2007.04613.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reflex regulation of renal nerve activity in cardiac failure1994 · 129 citations
  2. 2The renin-angiotensin system during acute myocardial ischemia in dogs.1990 · 62 citations
  3. 3Progression of heart failure after myocardial infarction in the rat2001 · 180 citations
  4. 4Nephrectomy, converting enzyme inhibition, and angiotensin peptides.1993 · 181 citations
  5. 5Reflex suppression of renin release by ventricular receptors with vagal afferents1977 · 35 citations