Key result
Enalapril decreased arterial pressure and cardiac mass but the inotropic response to isoproterenol remained depressed in both hypertensive and treated rats (p<0.05).
Why the study?
Does enalapril improve the inotropic response to isoproterenol in renal hypertensive rats?
Does enalapril improve the inotropic response to isoproterenol in renal hypertensive rats?
p-value: p=<0.05
Enalapril treatment reduces cardiac mass and arterial pressure but does not normalize the depressed contractile response to beta-adrenergic stimulation in renal hypertensive rats.
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Enalapril reduces pressure and mass without restoring beta-adrenergic inotropy in hypertensive rats; leaves open translation to human cardiac dysfunction.
Llambí et al. (1992) studied Renal hypertension (n=28). Enalapril vs. Vehicle was evaluated on Increment in maximal rate of rise of tension (+T) and maximal velocity of relaxation (-T) in response to isoproterenol (p=<0.05). Enalapril decreased arterial pressure and cardiac mass but the inotropic response to isoproterenol remained depressed in both hypertensive and treated rats (p<0.05).
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