Key result
Enalapril treatment (5-15 mg/kg/day) in normal rats did not change basal cardiac contractility, but significantly lowered blood pressure and ventricular DNA content (p<0.05 vs controls).
Why the study?
Does enalapril alter basal contractility and inotropic response to isoproterenol in normal rats?
Does enalapril alter basal contractility and inotropic response to isoproterenol in normal rats?
In normal rats, enalapril does not affect cardiac contractility but lowers blood pressure and may modify cardiomyocyte DNA content.
Enalapril preserves basal contractility in normal rats; leaves open translation to diseased models or clinical use.
Previous experiments showed that enalapril (EN) treatment as well as enalaprilic acid, when added to the perfusion bath, diminish the inotropic response of the papillary muscles to isoproterenol (ISO). The main objective of this study was to evaluate, in normal rats, the effect of EN on basal contractility and inotropic response to ISO on the whole perfused ventricles (Langendorff preparation). Blood pressure (BP), increase in body weight (IBW), ventricular weight/body weight ratio (R) and concentration of ventricular proteins and DNA were also analyzed. Five groups were studied: EN10: 5 mg/kg/day, 10 days; EN21(L): 5mg/kg/day, 21 days; EN21(H): 15 mg/kg/day, 21 days. C10 and C21 were untreated controls. Cardiac contractility was evaluated by the maximal developed pressure, maximal rate of rise of pressure and maximal velocity of relaxation; no changes were found due to EN treatments either on basal conditions or on ISO stimulation. Significant differences (p<0.05 vs C21) were: lower BP and R in EN21(L) and EN21(H), slower IBW in EN21(H), decreased ventricular DNA in EN21(H). In conclusion, daily treatment for ten or twenty one days with enalapril does not change either basal cardiac contractile performance or inotropic response to ISO in the Langendorff preparation. Longterm treatment with EN seems to modify nuclear processes involved in cardiomyocite DNA content.
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Mazzadi et al. (1998) studied Normal rats. Enalapril vs. Untreated controls was evaluated on Basal contractility and inotropic response to isoproterenol. Enalapril treatment (5-15 mg/kg/day) in normal rats did not change basal cardiac contractility, but significantly lowered blood pressure and ventricular DNA content (p<0.05 vs controls).
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