December 1, 1987Journal of Cardiovascular Pharmacology

Increased Survival in Rats with Congestive Heart Failure Treated with Enalapril

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Why the study?

Does enalapril prolong survival in a rat model of congestive heart failure post-myocardial infarction?

Population

132 rats with a healed myocardial infarction

Comparison

Enalapril in the drinking water for up to 365 days vs Tap water

Design

Preclinical, Randomized

Follow-up

365 days

Authors

CSCharles S. SweetRoche (Switzerland)SEScott E. EmmertUnited States Military Academy ISInez I. StabilitoMayo Clinic

Discussion

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Implication

Does not inform clinical practice; extends preclinical survival data in post-MI rat heart failure but requires human trials.

Structured PICO

Does enalapril prolong survival in a rat model of congestive heart failure post-myocardial infarction?

Population

132 rats (75 sham, 57 MI) with a healed myocardial infarction (an experimental model with hemodynamic characteristics of congestive heart failure)

Intervention

Enalapril in the drinking water (17-25 mg/L, approximately 1.0 mg/kg/day) for up to 365 days

Comparator

Tap water

Outcome

Survival (date of spontaneous death)hard clinical

Long-term enalapril therapy significantly prolonged survival in a rat model of congestive heart failure following myocardial infarction.

Cite This Study

Sweet et al. (1987) studied this question.

synapsesocial.com/papers/6a7f40fde052db6f994a5b85 https://doi.org/10.1097/00005344-198712000-00005

Topics

Heart failure HFrEF treatment

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Increased Survival in Rats with Congestive Heart Failure Treated with Enalapril

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Increased Survival in Rats with Congestive Heart Failure Treated with Enalapril

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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