Key result
Experimental myocardial infarction in sheep did not lead to renal sodium or volume retention during chronic volume loading compared to normal controls, accompanied by elevated natriuretic peptides (P<0.05).
Why the study?
Does chronic volume loading cause sodium or volume retention in sheep with experimental MI compared to normal controls?
Does chronic volume loading cause sodium or volume retention in sheep with experimental MI compared to normal controls?
Natriuretic peptides appear to play a pivotal role in preserving volume and electrolyte balance in the early stages of post-MI cardiac dysfunction.
Questions post-MI sodium retention dogma in early dysfunction; leaves open natriuretic peptide compensation pending translational studies.
The impaired ability to excrete sodium is a key feature of established congestive heart failure and is also apparent in asymptomatic left ventricular (LV) impairment. However, few studies have examined responses to chronic volume loading immediately post-myocardial infarction (MI). Experimental MI was induced in six sheep by thrombogenic coil coronary artery occlusion, and resulted in significant LV dysfunction with reduced LV ejection fraction ( P =0.001) and subsequent remodelling (increased LV volumes, P =0.015). Chronic volume loading with 2, 3 and 4 litres/day intravenous saline (each for 7 days) showed no evidence of renal sodium or volume retention in sheep with experimental MI compared with six normal control sheep. Plasma levels of brain natriuretic peptide (BNP), N-terminal pro-BNP and cGMP (all P <0.05) were higher in the MI group compared with normal control sheep. There were no differences in haemodynamics, body mass or renin-aldosterone levels between groups. This study provides evidence that natriuretic peptides play a pivotal role in preserving volume/electrolyte balance in the early stages of post-MI cardiac dysfunction.
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Charles et al. (2003) studied Post-myocardial infarction (n=12). Experimental myocardial infarction vs. Normal control sheep was evaluated on Renal sodium or volume retention. Experimental myocardial infarction in sheep did not lead to renal sodium or volume retention during chronic volume loading compared to normal controls, accompanied by elevated natriuretic peptides (P<0.05).
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