Factors associated with heart failure in patients with interstitial lung diseases

Introduction. Investigation of relationships between interstitial lung diseases (ILD) and development of heart failure would be useful for determining target therapy of heart failure (HF) among such patients. Aims.To study intracardiac hemodynamic and factors associated with its dysfunction among patients with ILD. 40 patients including: 34 with Chronic Hypersensitivity Pneumonitis (HP) and 6 with idiopathic pulmonary fibrosis (IPF). Methods. Pulmonary high-resolution computed tomography, echocardiography, spirometry, diffusing lung capacity for carbon monoxide (DLCO), bodypletysmography, blood oxygen (PaO ) were estimated. Results. 55.9% of patients with HP and all patients with IPF had a «cor pulmonale» with diastolic disfunction (DD), and 40% of them also had systolic dysfunction of right ventricle (RV). DD of left ventricle (LV) of I type was found among 10% of patients. 20% of patients were diagnosed with high pulmonary pressure (PP). The basal diameter of right ventricle (BDRV) correlated with DLCO (r=-0,718, p=0,004), PaO (r=-0,690, p=0,006), lung fibrosis (LF) (r=0,602, p=0,002). Tricuspid Annular Plane Systolic Excursion (TAPSE) correlated with mitral E/E’ ratio, tricuspid E/E’ ratio, total lung capacity (TLC) and LF (r=-0,753, p=0,002). Parameters of DD of RV significantly correlated with BDRV, TLC, DLCO, LF. Mitral E/E’ ratio correlated with DLCO and LF. PP corresponded with DLCO, DD of LV, LF (r=0,536, p=0,03) Conclusions. Correlation of LF with parameters of heart failure makes it one of the targets for ILD therapy as well as HF associated with ILD.