Key result
Bioinformatics identifies five crucial differentially expressed genes shared between HF and AF.
Why the study?
Patients with both heart failure and atrial fibrillation experience worse prognoses than those with either condition alone, but their common pathogenesis and shared therapeutic targets remain unclear.
Identified five crucial genes (FRZB, SFRP4, ENTPPL, AQP4, C1orf105) and the Wnt pathway as potential common therapeutic targets for patients with concurrent heart failure and atrial fibrillation.
Hypothesis-generating for shared targets in HF and AF; requires validation before any clinical consideration.
Background and objectives: In clinical practice, we observed that the prognoses of patients with heart failure and atrial fibrillation were worse than those of patients with only heart failure or atrial fibrillation. The study aims to get a better understanding of the common pathogenesis of the two diseases and find new therapeutic targets. Materials and Methods: We downloaded heart failure datasets and atrial fibrillation datasets from the gene expression omnibus database. The common DEGs (differentially expressed genes) in heart failure and atrial fibrillation were identified by a series of bioinformatics methods. To better understand the functions and possible pathways of DEGs, we performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Results: We identified 22 up-regulated genes and 14 down-regulated genes in two datasets of heart failure and 475 up-regulated and 110 down-regulated genes in atrial fibrillation datasets. In addition, two co-upregulated (FRZB, SFRP4) and three co-downregulated genes (ENTPPL, AQP4, C1orf105) were identified. GO enrichment results showed that these common differentially expressed genes were mainly concentrated in the signal regulation of the Wnt pathway. Conclusions: We found five crucial genes in heart failure and atrial fibrillation, which may be potential therapeutic targets for patients with heart failure and atrial fibrillation.
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Zhuang et al. (2022) studied Heart failure and atrial fibrillation. Bioinformatics analysis of GEO datasets identified five crucial co-differentially expressed genes (FRZB, SFRP4, ENTPPL, AQP4, C1orf105) in heart failure and atrial fibrillation.
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