Key result
Meta-analysis establishes -16.4% as the lower limit of normal for 2D-RVGLS in healthy subjects.
Why the study?
The reference range, including the lower limit of normal, and factors associated with right ventricular systolic strain measurements are not well-established despite their prognostic value.
What are the normal reference ranges for right ventricular systolic strain by echocardiography in healthy subjects?
Population
4439 healthy subjects across 45 studies
Comparison
2D and 3D echocardiographic RV strain measurements
Design
Meta-analysis
Authors
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Establishes -16.4% as 2D-RVGLS lower limit of normal; extends normative data to standardize clinical interpretation and research.
Meta-Analysis (n=4,439)
What are the normal reference ranges for right ventricular systolic strain by echocardiography in healthy subjects?
This meta-analysis establishes the pooled means and lower limits of normal for 2D and 3D right ventricular systolic strains in healthy subjects, providing thresholds for clinical use.
Wang et al. (2021) conducted a meta-analysis in Healthy subjects (n=4,439). Two-dimensional right ventricular global longitudinal strain (2D-RVGLS) measurement was evaluated on Pooled lower limit of normal (LLN) for 2D-RVGLS (95% CI -17.3%, -15.5%). In healthy subjects, the pooled lower limit of normal for two-dimensional right ventricular global longitudinal strain was -16.4%, establishing a reference threshold for abnormal strain.
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