The combination of elevated waist circumference (≥90 cm) and fasting triglycerides (≥2.0 mmol/L) identified men at significantly increased risk of coronary artery disease (OR 3.6, P<0.03).
Observational (n=472)
Does the simultaneous measurement of waist circumference and fasting triglycerides identify men with an atherogenic metabolic triad and increased risk of CAD?
Simultaneous measurement of waist circumference and fasting triglycerides can serve as an inexpensive screening tool to identify men at high risk for CAD and the atherogenic metabolic triad.
Effect estimate: OR 3.6
p-value: p=<0.03
BACKGROUND: The present study tested the hypothesis that simple variables, such as waist circumference and fasting plasma triglyceride (TG) concentrations, could be used as screening tools for the identification of men characterized by a metabolic triad of nontraditional risk factors (elevated insulin and apolipoprotein apo B and small, dense LDL particles). METHODS AND RESULTS: Results of the metabolic study (study 1) conducted on 185 healthy men indicate that a large proportion (>80%) of men with waist circumference values >/=90 cm and with elevated TG levels (>/=2.0 mmol/L) were characterized by the atherogenic metabolic triad. Validation of the model in an angiographic study (study 2) on a sample of 287 men with and without coronary artery disease (CAD) revealed that only men with both elevated waist and TG levels were at increased risk of CAD (odds ratio of 3.6, P<0.03) compared with men with low waist and TG levels. CONCLUSIONS: It is suggested that the simultaneous measurement and interpretation of waist circumference and fasting TG could be used as inexpensive screening tools to identify men characterized by the atherogenic metabolic triad (hyperinsulinemia, elevated apo B, small, dense LDL) and at high risk for CAD.
Lemieux et al. (2000) conducted an observational in Coronary artery disease and atherogenic metabolic triad (n=472). Elevated waist circumference (≥90 cm) and fasting triglycerides (≥2.0 mmol/L) vs. Low waist circumference and triglyceride levels was evaluated on Coronary artery disease (OR 3.6, p=<0.03). The combination of elevated waist circumference (≥90 cm) and fasting triglycerides (≥2.0 mmol/L) identified men at significantly increased risk of coronary artery disease (OR 3.6, P<0.03).
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