Key result
Obesity is linked to ~43-fold higher depression risk in women compared to being overweight.
Why the study?
Obesity and depression are major causes of disability, but the link between depression, BMI, and metabolic syndrome components had not been well explored.
Is body mass index or metabolic syndrome associated with depression in subjects screened for a weight loss trial?
Cross-Sectional (n=150)
Is body mass index or metabolic syndrome associated with depression in subjects screened for a weight loss trial?
Effect estimate: OR 42.62 (95% CI 5.74-316.3)
p-value: p=< 0.0001
Body mass index is a strong independent predictor of depression, particularly in women, whereas metabolic syndrome and insulin resistance showed no significant association.
Obesity signals higher depression risk in weight-loss trial candidates, especially women; leaves open causality and screening utility.
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Pelluri et al. (2021) conducted a cross-sectional in Depression and Obesity (n=150). Obesity vs. Overweight was evaluated on Risk of depression in women (OR 42.62, 95% CI 5.74-316.3, p=< 0.0001). Obesity was a strong predictor of depression compared to being overweight, with a substantially higher risk in women (OR 42.62; 95% CI 5.74-316.3) than in men.
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