Key result
An increasing number of metabolic syndrome components was significantly associated with higher predicted PHQ-9 depression scores in patients with insulin resistance (P for trend < 0.05).
Why the study?
Does an increased number of metabolic syndrome components increase the severity of depressive symptoms in participants with insulin resistance?
Cross-Sectional (n=3,331)
Does an increased number of metabolic syndrome components increase the severity of depressive symptoms in participants with insulin resistance?
Effect estimate: adjusted β coefficient 3.048 for 5 MetS components
p-value: p=< 0.05
In patients with insulin resistance, a higher number of metabolic syndrome components, particularly low HDL-C, is significantly associated with increased severity of depressive symptoms.
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Does not warrant practice change; leaves open whether metabolic syndrome components influence depressive symptoms in insulin resistance.
Liaw et al. (2015) conducted a cross-sectional in Depression and Metabolic Syndrome (n=3,331). Metabolic syndrome components vs. Fewer metabolic syndrome components was evaluated on Predicted PHQ-9 scores (adjusted β coefficient 3.048 for 5 MetS components, p=< 0.05). An increasing number of metabolic syndrome components was significantly associated with higher predicted PHQ-9 depression scores in patients with insulin resistance (P for trend < 0.05).
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