Why the study?
Does intravenous 20% saline affect pulmonary and systemic pressures in anesthetized dogs?
Does intravenous 20% saline affect pulmonary and systemic pressures in anesthetized dogs?
Intravenous hypertonic saline in dogs induces marked hemodynamic changes, likely due to chemoreceptor-mediated spasm at the pulmonary vein-left atrial junction.
Highlights hemodynamic risks in canine models; leaves open human relevance of hypertonic saline.
The intravenous injection of 20 per cent saline in anesthetized closed chest dogs causes a rise in pulmonary venous, pulmonary arterial, right ventricular and peripheral venous pressures. Left atrial pressure does not change or falls, and systemic arterial pressure decreases very markedly. These changes are shown to result from spasm at the pulmonary vein--left atrial junction. Stimulation of chemoreceptors in this region is assumed to be the cause of the spasm.
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Eliakim et al. (1958) studied this question.
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