Key result
Intra-arterial injection of hypertonic solutions in dogs increased arterial blood pressure (+42/+20 mm Hg), heart rate (+20 beats/min), and respiratory rate (+140%).
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No direct clinical implications from canine data; leaves open translation to human hemodynamic responses.
Lasser et al. (1960) studied this question. Intra-arterial injection of hypertonic and hypotonic solutions vs. Isotonic saline, dextrose, urea solutions, and whole blood was evaluated on Arterial blood pressure, heart rate, and respiratory rate. Intra-arterial injection of hypertonic solutions in dogs increased arterial blood pressure (+42/+20 mm Hg), heart rate (+20 beats/min), and respiratory rate (+140%).
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