Key result
An 8.5 binucleated myocyte cutoff identifies increased male heart weight.
Why the study?
Establishing an association between myocyte hypertrophy and heart weight may help assess cardiac hypertrophy when measuring heart weight has limitations.
Does the number of binucleated myocytes correlate with increased heart weight in an adult White population?
Observational
Does the number of binucleated myocytes correlate with increased heart weight in an adult White population?
The number of binucleated myocytes in the left ventricular free wall correlates with increased heart weight and may serve as a complementary histological marker for cardiac hypertrophy.
Answers are grounded in this paper and cite their sources.
May support binucleated myocyte count as a hypertrophy marker in males; leaves open prospective validation before clinical use.
Hypertrophy of the heart is assessed by heart weight (and dimensions) and myocyte hypertrophy. Establishing an association between the two may be useful in assessing hypertrophy in cases where there are limitations in assessing the heart weight. This preliminary study explored the association between the number of binucleated myocytes (a feature of myocyte hypertrophy) in a randomly chosen single high-power field of the left ventricular free wall and heart weight in an adult White population. It also compared the number of binucleated myocytes between cases with increased heart weight (>400 g in female and >500 g in male) and cases with normal heart weight. Heart weight and number of binucleated myocytes correlated significantly in male only. Increased heart weight had a significantly higher number of binucleated myocytes, with 8.5 binucleated myocytes being able to segregate cases with increased heart weight (74% sensitivity and 79% specificity). The results of this study showed the number of binucleated myocytes may have a complementary role in assessing hypertrophy of the heart.
No takes yet. Share an insight, caveat, or question.
Gadsby et al. (2023) conducted an observational in Cardiac hypertrophy. Binucleated myocytes assessment vs. Normal heart weight was evaluated on Correlation between number of binucleated myocytes and heart weight. The number of binucleated myocytes correlated significantly with heart weight in males, with a cutoff of 8.5 myocytes identifying increased heart weight with 74% sensitivity and 79% specificity.
Synapse has enriched 10 related papers. Consider them for comparative context: