Key result
Higher TyG index is linked to ~0.9 mmHg higher cSBP per unit in hypertensive adults.
Why the study?
Data are limited regarding the correlation between the triglyceride-glucose index, a surrogate for insulin resistance, and central blood pressure in hypertension.
Is a higher triglyceride-glucose (TyG) index associated with elevated central systolic blood pressure in hypertensive adults?
Cross-Sectional (n=9,249)
Yes
Is a higher triglyceride-glucose (TyG) index associated with elevated central systolic blood pressure in hypertensive adults?
Effect estimate: β 0.92 (95% CI 0.53-1.31)
p-value: p=<0.001
The triglyceride-glucose index is positively associated with central systolic blood pressure in hypertensive adults, suggesting its potential as a marker for vascular function.
May mark vascular stiffness in hypertension; hypothesis-generating, needs longitudinal validation before clinical use.
BACKGROUND: While studies have suggested the association between triglyceride-glucose (TyG) index, a reliable surrogate for insulin resistance and hypertension data are limited to the correlation of TyG and central blood pressure. This study aims to test the hypothesis that a higher TyG index is associated with elevated central systolic blood pressure (cSBP). METHODS: A total of 9249 Chinese hypertensive adults from the H-type Hypertension and Stroke Prevention and Control Project were analyzed in this study. cSBP was measured noninvasively using an A-Pulse CASPro device. TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Smoothing curve and multivariate linear regression models [beta coefficient (β) with 95% CI] were applied to analyze the association between TyG index and cSBP. Subgroup analyses were conducted to explore potential modifications to such a correlation. RESULTS: < 0.001), which is in accordance with the result of the smoothing curve. The association between TyG index and cSBP appears robust in all tested subgroups. CONCLUSIONS: TyG index is positively and independently associated with cSBP among hypertensive adults. Our study result suggests that TyG index might serve as an effective marker for vascular function.
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Wang et al. (2022) conducted a cross-sectional in Hypertension (n=9,249). Triglyceride-glucose (TyG) index was evaluated on Central systolic blood pressure (cSBP) (β 0.92, 95% CI 0.53-1.31, p=<0.001). The triglyceride-glucose index was independently and positively associated with central systolic blood pressure among hypertensive adults, with cSBP increasing by 0.92 mmHg per 1 unit increase in TyG index.
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