Key result
Lone PAF patients show pronounced baroreflex impairment during upright tilt compared to healthy controls.
Why the study?
Abnormal neural control of atria is implicated in paroxysmal atrial fibrillation pathogenesis, prompting analysis of the baroreceptor reflex's role in heart rate regulation during upright tilt in patients with lone PAF.
Do patients with lone paroxysmal atrial fibrillation have impaired baroreflex sensitivity and autonomic dysfunction compared to healthy individuals?
Population
68 patients with lone PAF and 34 healthy individuals
Comparison
Patients with lone PAF vs healthy individuals during upright tilt
Authors
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Baroreflex impairment may mark autonomic dysfunction in lone PAF; hypothesis-generating and requires prospective validation before clinical use.
Case-Control (n=102)
Do patients with lone paroxysmal atrial fibrillation have impaired baroreflex sensitivity and autonomic dysfunction compared to healthy individuals?
Patients with lone paroxysmal atrial fibrillation exhibit pronounced baroreflex impairment and autonomic dysfunction, suggesting the baroreflex effectiveness index could serve as a marker for this dysfunction.
Ferreira et al. (2023) conducted a case-control in Lone paroxysmal atrial fibrillation (n=102). Upright tilt (HUT) vs. Healthy individuals was evaluated on Baroreflex sensitivity (BRS), number of systolic blood pressure (BP) ramps, and the baroreflex effectiveness index (BEI). Lone PAF patients showed pronounced baroreflex impairment during upright tilt, with delayed baroreceptor activation and lower baroreflex effectiveness index compared to healthy individuals.
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