Key result
Presentation with stable ventricular tachycardia independently predicted appropriate ICD therapy, and replacement devices were as likely to deliver therapy as the original implants (P=0.8).
Why the study?
What are the predictors of appropriate ICD therapy in a general ICD population, and does the likelihood of therapy differ between original and replacement ICDs?
Observational (n=161)
No
What are the predictors of appropriate ICD therapy in a general ICD population, and does the likelihood of therapy differ between original and replacement ICDs?
Patients presenting with stable VT have a higher probability of receiving appropriate ICD therapy, and replacement devices are as likely to deliver therapy as the original implants.
Stable VT presentation was associated with higher appropriate ICD therapy; supports risk stratification but leaves replacement device equivalence open in observational data.
BACKGROUND: It would be useful to identify patients at high risk of implantable cardioverter defibrillator (ICD) therapy via additional antiarrhythmic measures to minimize the morbidity of ICD therapies. OBJECTIVE: We assessed baseline characteristics for predictors of device therapy in a general ICD population. We also compared the likelihood of therapy delivery by replacement ICDs implanted for battery depletion with the original implants. METHODS: Clinical and ICD interrogation data from patients followed up at a UK center were analyzed looking for predictors of appropriate ICD therapy. Univariate and multivariate analysis was performed using Cox regression. We compared time to first appropriate therapy between first and second ICDs in patients who had undergone ICD replacement for battery depletion by log-rank testing. RESULTS: One hundred and sixty-one patients were studied (129 men, age 65.7 +/- 12.9 years, follow-up 908 +/- 676 days). Appropriate therapy was delivered in 68 patients (42%). Univariate risk factors for appropriate ICD therapy were presentation with stable ventricular tachycardia (VT) (P = 0.0002), ischemic etiology (P = 0.03), tiered therapy programmed ICDs (P = 0.01), and beta-blocker use (P = 0.001). Stable VT and beta blocker use were independent predictors of ICD therapy on multivariate analysis. Thirty-three patients (20%) had at least one ICD replacement. Time to first appropriate therapy was no different between first and second ICD implants (P = 0.8). CONCLUSION: Patients who present with cardiovascularly stable VT have a higher probability of receiving appropriate ICD therapy than those who do not. Following battery depletion of an original ICD, the replacement device is no less likely to administer therapy than the first.
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Koa‐Wing et al. (2007) conducted an observational in Patients with implantable cardioverter defibrillators (ICDs) (n=161). Predictors of ICD therapy (stable VT, beta-blocker use) and replacement ICDs vs. Patients without predictors / Original ICD implants was evaluated on Appropriate ICD therapy delivery. Presentation with stable ventricular tachycardia independently predicted appropriate ICD therapy, and replacement devices were as likely to deliver therapy as the original implants (P=0.8).
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