Key result
The presence of brain microbleeds was significantly associated with antiplatelet-related intracerebral haemorrhage (adjusted OR 1.33 per additional microbleed; 95% CI 1.06-1.66; p=0.013).
Why the study?
Are brain microbleeds on MRI associated with an increased risk of antiplatelet-related intracerebral haemorrhage?
Case-Control (n=81)
Single-blind
No
Are brain microbleeds on MRI associated with an increased risk of antiplatelet-related intracerebral haemorrhage?
Effect estimate: OR 1.33 per additional microbleed (95% CI 1.06 to 1.66)
Absolute Event Rate: 81% vs 19%
p-value: p=0.013
Brain microbleeds are significantly associated with antiplatelet-related intracerebral haemorrhage, suggesting they may help identify patients at high risk for bleeding complications from antiplatelet therapy.
No takes yet. Share an insight, caveat, or question.
Microbleeds may aid bleeding risk stratification on antiplatelets; hypothesis-generating and should not yet change practice.
Gregoire et al. (2010) conducted a case-control in Intracerebral haemorrhage (n=81). Brain microbleeds vs. Matched controls without ICH was evaluated on Presence of brain microbleeds (OR 1.33 per additional microbleed, 95% CI 1.06 to 1.66, p=0.013). The presence of brain microbleeds was significantly associated with antiplatelet-related intracerebral haemorrhage (adjusted OR 1.33 per additional microbleed; 95% CI 1.06-1.66; p=0.013).
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