Key result
The presence of cerebral microbleeds was independently associated with an increased risk of recurrent intracerebral hemorrhage (OR 7.383) in patients treated with warfarin following ischemic stroke.
Why the study?
Does the presence of cerebral microbleeds increase the risk of intracerebral hemorrhage in patients treated with warfarin following atrial fibrillation-associated cardioembolic infarction?
Observational (n=87)
No
Does the presence of cerebral microbleeds increase the risk of intracerebral hemorrhage in patients treated with warfarin following atrial fibrillation-associated cardioembolic infarction?
Odds Ratio: 7.383 (95% CI 1.052–51.83)
Absolute Event Rate: 86.7% vs 38.9%
p-value: p=0.0443
The presence of cerebral microbleeds on MRI is an independent risk factor for warfarin-related intracerebral hemorrhage in patients with prior cardioembolic stroke.
No takes yet. Share an insight, caveat, or question.
May warrant caution with warfarin post-cardioembolic stroke if microbleeds present; leaves open need for RCTs to guide practice.
Ueno et al. (2008) conducted an observational in Acute recurrent stroke (intracerebral hemorrhage or ischemic stroke) (n=87). Cerebral microbleeds vs. Absence of cerebral microbleeds was evaluated on Recurrent intracerebral hemorrhage (ICH) (OR 7.383, 95% CI 1.052-51.830, p=0.0443). The presence of cerebral microbleeds was independently associated with an increased risk of recurrent intracerebral hemorrhage (OR 7.383) in patients treated with warfarin following ischemic stroke.
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