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September 1, 1990Endocrinology

A Potential Role for Phospholipase-D in the Angiotensin-II-Induced Stimulation of Aldosterone Secretion from Bovine Adrenal Glomerulosa Cells*

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Population

Cultured bovine adrenal glomerulosa cells

Design

Preclinical

Authors

WBWendy B. BollagAugusta UniversityPBPaula Q. BarrettUniversity of VirginiaCICarlos M. IsalesAugusta University

Discussion

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Implication

No clinical implications from this animal study; leaves open PLD's role in Ang II-aldosterone pathways for human validation.

Structured PICO

P
Population
Cultured bovine adrenal glomerulosa cells
I
Intervention
Angiotensin-II (Ang II), exogenous phospholipase-D (PLD), and calcium channel agonist Bay K 8644
O
Outcome
Aldosterone secretion rate and diacylglycerol (DAG) levelssurrogate

PLD-induced DAG production may play an important role in the Ang II-mediated stimulation of aldosterone secretion from the adrenal zona glomerulosa.

Cite This Study

Bollag et al. (1990) studied this question.

synapsesocial.com/papers/6a156b3f814bf8ec9a4e9055https://doi.org/10.1210/endo-127-3-1436
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atrial natriuretic peptide differentially modulates T- and L-type calcium channels1990 · 37 citations
  2. 2PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT1951 · 318,728 citations
  3. 3Muscarinic Receptor Activation of Phosphatidylcholine Hydrolysis1989 · 144 citations
  4. 4Regulation of 1,2-Diacylglycerol Production by Angiotensin-II in Bovine Adrenal Glomerulosa Cells1990 · 47 citations
  5. 5Signaling through phosphatidylcholine breakdown.1990 · 1,358 citations